Adenosine Mapping for Adenosine-Dependent Accessory Pathway Ablation

Adenosine mapping for adenosine-dependent accessory pathway ablation.

BACKGROUND This study describes the use of adenosine during ablation procedures to allow conduction through adenosine-dependent accessory pathways (APs), which are inactive at the time of the procedure. The technique allows for successful mapping and ablation of these pathways. METHODS Retrospective review of all patients undergoing AP ablation from 1998 to 2008 to identify patients with abse...

Resumption of dormant accessory pathway conduction with adenosine administration: a simple intervention to ensure successful accessory pathway ablation.

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Adenosine can improve the intra-atrial conduction block along the mitral annulus during accessory pathway ablation.

A 10-year-old boy with a supraventricular tachycardia was referred for catheter ablation. An electrophysiologic study revealed a left lateral concealed accessory pathway (AP). A few radiofrequency (RF) applications targeting the AP resulted in an inadvertent intra-atrial conduction block at the mitral isthmus without any damage to the AP. Adenosine was then administered during left ventricular ...

Mechanisms and Clinical Significance of Adenosine-InducedDormant Accessory Pathway Conduction Following Catheter Ablation

Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines.

Pharmacological studies suggest that A(2B) adenosine receptors mediate proinflammatory effects of adenosine. This concept was recently challenged by the finding that A(2B) adenosine receptor knockout (A(2B)KO) mice had moderate inflammation due to elevated basal plasma tumor necrosis factor (TNF)-alpha and an exaggerated response to lipopolysaccharide (LPS) challenge. However, it is unclear whe...